Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders
نویسندگان
چکیده
منابع مشابه
Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders
Adequate maturation of neurons and their integration into the hippocampal circuit is crucial for normal cognitive function and emotional behavior, and disruption of this process could cause disturbances in mental health. Previous reports have shown that mice heterozygous for a null mutation in α -CaMKII, which encodes a key synaptic plasticity molecule, display abnormal behaviors related to sch...
متن کاملThe Role of Dentate Gyrus Neurogenesis in Neuropsychiatric Disorders
The special issue reviews the most recent developments in dentate gyrus (DG) neurogenesis with regard to neuropsychiatric disorders. A few laboratories worldwide have contributed to this special issue, and their contributions have showcased the current efforts in understanding the functional significance of DG neurogenesis in depression, psychosis, and addiction. Additionally, a promising thera...
متن کامل[Immaturity of brain as an endophenotype of neuropsychiatric disorders].
Schizophrenia and bipolar disorder are severe neuropsychiatric disorders, affecting about 1% of the population. Identifying endophenotypes in the brains of neuropsychiatric patients is now considered the way to understand the underlying mechanisms and to improve therapeutic outcomes. However, the endophenotypes and brain mechanisms of the disorders remain unknown. We have previously reported th...
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We used whole cell patch clamp and gramicidin perforated patch recordings in hippocampal slices to study gamma-aminobutyric acid (GABA) currents in granule cells (GCs) from juvenile rat dentate gyrus (DG). GCs are generated postnatally and asynchronously such that they can be detected at different stages of their maturation in DG within the first month. In contrast, inhibitory interneurons are ...
متن کاملSynchronized spike waves in immature dentate gyrus networks.
At early developmental stages, immature neuronal networks of the neocortex and hippocampus spontaneously exhibit synchronously oscillating activities, which are believed to play roles in normal circuit maturation. The tissue development of the dentate gyrus (DG) in the hippocampal formation is exceptionally late compared with other brain regions and persists until postnatal periods. Using patch...
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ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2013
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2013/318596